Method

Source: Alvarenga et al (2019)

Source: Alvarenga et al (2019)
Conclusion
The experts reached a consensus regarding the use of factor VIII (FVIII) replacement therapy in combination with emicizumab, an antibody prophylaxis in the treatment of high-risk hemophilia patients.
This includes the appropriate use of FVIII in combination with emicizumab during and immediately post-surgery for patients with elective surgery and episodic FVIII followed by emicizumab for newborns with post-circumcision bleeding.
Most of the panelists preferred FVIII over emicizumab due to established evidence on safety and efficacy.
These recommendations complement existing treatment guidelines and support physicians in the management of hemophilia A patients without inhibitors.
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